ANTIANEMIA SUPPLEMENTATION COMBINATION WITH VITAMIN C ON HEMOGLOBIN LEVELS AMONG PREGNANT WOMEN IN PRIMARY HEALTH CARE CENTER, JEPARA, INDONESIA

Poppy Diah Palupi(1*), Mohammed Safwan Ali Khan(2), Kukilo Kenuk Karseno(3),

(1) Department of Pharmacology and Clinical Pharmacy, Nusaputera School of Pharmaceutical Science, Semarang, Indonesia
(2) Department of Biomedical Sciences, School of Medicine, Nazarbayev University, 5/1 KereiZhanibek Khandar Str.53 Kabanbay Batyr Avenue, Nur-Sultan city, 010000 Kazakhstan
(3) Department of Pharmacology and Clinical Pharmacy, Nusaputera School of Pharmaceutical Science, Semarang, Indonesia
(*) Corresponding Author

Abstract


Blood volume escalation during pregnancy leads to an increase in iron needs. Pregnant women are prone to maternal anemia that is caused by iron, folic acid, vitamins B2, B12, A, and C deficiency and may serve as causative factors that aggravate anemia. Concerning the problem, this clinical investigation determined the effect of antianemia supplementation and its combination with vitamin C on hemoglobin levels during pregnancy. This study is a quasi-experimental involving 34 patients who consumed antianemia supplements with or without vitamin C. The treatment group was given a combination of antianemia supplement Fe Fumarate 180 mg-Folic Acid 400 mcg and vitamin C 100 mg. The positive-control group was administrated with antianemia supplement Fe Fumarate 180 mg-Folic Acid 400 mcg. After 28 days, blood samples were taken to measure the hemoglobin levels. The hemoglobin levels were found to have a statistically significant difference (p<0.05) between that group receiving a combination of antianemia-vitamin C and the other group administered with antianemia alone.


Keywords


Antianemia supplement; vitamin C; pregnancy; hemoglobin level

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References


Abbaspour, N., Hurrell, R., Kelishadi, R., 2014. Review on iron and its importance for human health. Journal of Research in Medical Sciences.

Abiselvi, A., Gopalakrishnan, S., Umadevi, R., Susilowati, Rizqi Fajri Ramadhani, Andi Sri Suriati Amal, F., 2017. Anemia among Pregnant Women in a Rural Area of Kancheepuram District, Tamil Nadu. International Journal Of Community Medicine And Public Health, 4(7), 2400.

Abu-Ouf, N.M., Jan, M.M., 2015. The Impact of Maternal Iron Deficiency and Iron Deficiency Anemia on a Child’s Health. Saudi Medical Journal, 36(2), 146–149.

Adam, I., Ali, A.A., 2016. Anemia During Pregnancy, in: Nutritional Deficiency. Intech Open, pp. 110–126.

Almatsier, 2009. Prinsip Dasar Ilmu Gizi. Gramedia Utama, Jakarta.

Arisman, 2004. Gizi Dalam Daur Kehidupan: Buku Ajar Ilmu Gizi. Penerbit Buku kedokteran EGC, Jakarta.

Ayensu, J., Annan, R., Lutterodt, H., Edusei, A., Peng, L.S., 2020. Prevalence of Anemia and Low Intake of Dietary Nutrients in Pregnant Women Living in Rural and Urban Areas in the Ashanti Region of Ghana. PLoS ONE, 15(1).

Balay, K.S., Hawthorne, K.M., Hicks, P.D., Griffin, I.J., Chen, Z., Westerman, M., Abrams, S.A., 2010. Orange but Not Apple Juice Enhances Ferrous Fumarate Absorption in Small Children. Journal of Pediatric Gastroenterology and Nutrition, 50(5), 545–550.

Crompton, D.W.T., Nesheim, M.C., 2002. Nutritional Impact of Intestinal Helminthiasis during the Human Life Cycle. Annual Review of Nutrition, 22(1), 35–59.

De Camargo, R.M.S., Pereira, R.A., Yokoo, E.M., Schirmer, J., 2013. Factors Associated with Iron Deficiency in Pregnant Women Seen at a Public Prenatal Care Service. Revista de Nutricao, 26(4), 455–464.

Fei, C., 2015. Iron Deficiency Anemia: A Guide to Oral Iron Supplements. Clinical Correlation, 7(2), 21–28.

Gandasoebrata, 2007. Penuntun Laboratorium Klinik. Dian Rakyat, Jakarta.

Gernand, A.D., Schulze, K.J., Stewart, C.P., West, K.P., Christian, P., 2016. Micronutrient Deficiencies in Pregnancy Worldwide: Health Effects and Prevention. Nature Reviews Endocrinology.

Ghattas, H., Fulford, T., Prentice, A., 2003. Effect of Moderate Anemia on Later Mortality in Rural African Children. Lancet, 361(9374), 2048–2050.

Hallberg, L., Hulthen, L., 2000. Prediction of Dietary Iron Absorption: An Algorithm for Calculating Absorption and Bioavailability of Dietary Iron | The American Journal of Clinical Nutrition | Oxford Academic. The American Journal of Clinical Nutrition, 71(5), 1147–1160.

Jacob, J., Robert, A., 2005. Vitamin C, in: Modern Nutrition in Health and Disease. Waverly Company, Philadelphia.

Li, N., Zhao, G., Wu, W., Zhang, M., Liu, W., Chen, Q., Wang, X., 2020. The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial. JAMA network open, 3(11), e2023644.

McPherson, Pincus, 2011. Henry’s Clinical Diagnosis and Management Laboratory Methods, 22nd ed. Elsevier Saunders, Philadelphia.

Moustarah, F., Mohiuddin, S.S., 2020. Dietary Iron, in: Iron Metabolism. Springer US, 27–35.

Munasinghe, S., 2007. Anemia in Pregnancy in Malawi - A Review. Malawi Medical Journal, 18(4), 160.

Nair, M., Choudhury, M.K., Choudhury, S.S., Kakoty, S.D., Sarma, U.C., Webster, P., Knight, M., 2016. Association between Maternal Anemia and Pregnancy Outcomes: A Cohort Study in Assam, India. BMJ Global Health, 1(1).

Nasyidah, N., Wijayantie, H., Fitrianingrum, I., 2013. Hubungan Anemia dan Karakteristik Ibu Hamil Di Puskesmas Alianyang Pontianak, Jurnal Mahasiswa PSPD FK Universitas Tanjungpura.

Nemo, Maternal Health Group, 2020. Iron for Pregnant Women | MHNNS | Nutrition; Iron for Pregnant Women | MHNNS | Nutrition. Queensland.

Norsiah, W., 2015. Perbedaan Kadar Hemoglobin Metode Sianmethemoglobin Dengan dan tanpa Sentrifugasi Pada Sampel Leukositosis. Medical Laboratory Technology Journal, 1(2), 72–83.

Rejeki, S., Huda, A., 2014. Karakteristik ibu, konsumsi tablet fe dengan kejadian anemia pada kehamilan di wilayah kerja Puskesmas Kaliwungu Kabupaten Kendal, in: Prosiding Seminar Nasional & Internasional. Universitas Muhammadiyah Semarang, Semarang, pp. 206–209.

Rimawati, E., Kusumawati, E., Gamelia, E., Sumarah, S., Nugraheni, S.A., 2018. Food Supplement Interventions For Increasing Hemoglobin Level on Pregnant Women. Jurnal Ilmu Kesehatan Masyarakat, 9(3), 161–170.

Seifedine Kadry, Carla Sleem, Roudaina Abdel Samad, 2018. Hemoglobin Levels in Pregnant Women and Its Outcomes - MedCrave online. Biometrics & Biostatistics International Journal, 7(4), 326–336.

Shu, E.N., Ogbodoa, S.O., 2005. Role of Ascorbic Acid in the Prevention. Biomedical Research, 16(1).

Skolmowska, D., Głąbska, D., 2019. Analysis of Heme and Non-heme Iron Intake and Iron Dietary Sources in Adolescent Menstruating Females in a National Polish Sample. Nutrients, 11(5).

Stevens, G.A., Finucane, M.M., De-Regil, L.M., Paciorek, C.J., Flaxman, S.R., Branca, F., Peña-Rosas, J.P., Bhutta, Z.A., Ezzati, M., 2013. Global, Regional, and National Trends in Hemoglobin Concentration and Prevalence of Total and Severe Anemia in Children and Pregnant and Non-pregnant Women for 1995-2011: A Systematic Analysis of Population-representative Data. The Lancet Global Health, 1(1), e16.

Stoffel, N.U., von Siebenthal, H.K., Moretti, D., Zimmermann, M.B., 2020. Oral Iron Supplementation in Iron-deficient Women: How Much and How Often? Molecular Aspects of Medicine.

Teucher, B., Olivares, M., Cori, H., 2004. Enhancers of iron absorption: Ascorbic acid and other organic acids, in: International Journal for Vitamin and Nutrition Research. Int J Vitam Nutr Res, pp. 403–419.

Triharini, M., Nursalam, N., Sulistyono, A., Adriani, M., Hsieh, P.-L., 2019. Perceived Benefits and Intakes of Protein, Vitamin C and Iron in Preventing Anemia among Pregnant Women. Jurnal Ners, 13(2), 156.

Tsikouras, P., Deftereou, T., Anthoulaki, X., Bothou, A., Chalkidou, A., Gaitatzi, F., Tsirkas, I., Chalil Bourazan, A., Bampageorgaka, E., Stanulov, G., Chatzimichael, E., Michalopoulos, S.,

Petsidis, P., Iatrakis, G., Zervoudis, S., Lambropoulou, M., Rath, W., Galazios, G., 2020. Abortions in First Trimester Pregnancy, Management, Treatment, in: Induced Abortion and Spontaneous Early Pregnancy Loss - Focus on Management. Intech Open.

Tunçalp, Pena-Rosas, J.P., Lawrie, T., Bucagu, M., Oladapo, O.T., Portela, A., Metin Gülmezoglu, A., 2017. WHO recommendations on antenatal care for a positive pregnancy experience—going beyond survival. BJOG: An International Journal of Obstetrics and Gynaecology.

WHO, 2017. WHO I Nutritional anemias: tools for effective prevention and control NUTRITIONAL ANAEMIAS: TOOLS FOR EFFECTIVE PREVENTION AND CONTROL. Geneva, Switzerland.

WHO, 2001. Iron deficiency anemia. Assessment, prevention, and control. A guide for programme managers, 47–62.

Wiknjosastro, 2002. Ilmu Kandungan. Yayasan Bina Pustaka Sarwono Prawirohardjo, Jakarta.




DOI: https://doi.org/10.24071/jpsc.002922

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