EFEK PEMBERIAN JUS BUAH PISANG AMBON (Musa paradisiaca var. sapientum (L.) Kunt.) TERHADAP KADAR GLUKOSA DARAH TIKUS JANTAN GALUR WISTAR  YANG TERBEBANI GLUKOSA

Katherine Jessica Ariani; Yunita Linawati

doi:10.24071/jpsc.00123

EFEK PEMBERIAN JUS BUAH PISANG AMBON (Musa paradisiaca var. sapientum (L.) Kunt.) TERHADAP KADAR GLUKOSA DARAH TIKUS JANTAN GALUR WISTAR YANG TERBEBANI GLUKOSA

Katherine Jessica Ariani, Yunita Linawati

Abstract

This research is to know the effect of giving Musa paradisiaca var. sapientum (L.) Kunt. juice to the blood glucose levels and to know the most effective of giving Musa paradisiaca var. sapientum (L.) Kunt. dose to lower the blood glucose levels in rats with oral glucose tolerance. This research was experimental study with one way-complete-random design using 25 male rats were divided into five groups. The rats in group I (negative control) were given of CMC 1%, the group II rats were given 0.64mg/kgBW doses of Glibenclamide (positive control), and group III,IV and V were given 5, 10 and 20 ml/kgBW doses of Musa paradisiaca var. sapientum (L.) Kunt. juice. The hypoglycemic effect of Musa paradisiaca var. sapientum (L.) Kunt. juice was tested by following the Oral Glucose Tolerance Test (OGTT) method. The blood-glucose contents were taken, at 0 minutes before OGTT, and also taken at minutes of 15, 20, 45, 60, 90, 120, 180, and 240 after OGTT, from the tested animal that had been gotten the pre-treatment of negative control, positive control and Musa paradisiaca var. sapientum (L.) Kunt. juice. The blood glucose levels was determined by using enzymatis GOD-PAP method. The AUC^0-240 was statistically analyzed using one way ANOVA and Scheffe test with 95% convidence level. The result of this research showed that Musa paradisiaca var. sapientum (L.) Kunt. can lower on rats in burdened glucose. The effective dose of Musa paradisiaca var. sapientum (L.) Kunt. juice can lower glucose blood levels at 5ml/kgBW.

Keywords

Musa paradisiaca var. sapientum (L.) Kunt. juice; lowering blood

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References

Aenah, F., 2004. Pengaruh Pemberian Fraksi Etanol Ekstrak Etanolik Pisang Kapas (Musa paradisiaca L.) Terhadap Kadar Glukosa Darah Tikus Putih Jantan Galur Wistar (Rattus norvegicus) yang Dibebani Glukosa. Skripsi, Fakultas Farmasi, Univeristas Gajah Mada, Yogyakarta.

Aguilara Alarcon-, F.J., Roman-Ramos, R., Perez-Gutierrez, S., Aguilar-Contreras, A., Contreras-Weber, C.C., Flores-Saenz, J.L., 1998. Study of The Anti-Hyperglycemic Effect of Plants Used ss Antidiabetics. J. Ethnopharmacol, 61, 101110.

Ajani, E.O., Salau, B.A., Akinlolu, A.A., Ekor, M.N., and Soladoye M.O., 2010. Methanolic Extract of Musa sapientum Suckers Moderates Fasting Blood Glucose and Body Weigth of Alloxan Induced Diabetic Rats. Asian J. Biol. Scl, 1(1), 30-35.

Dalimartha, S., 2005. Ramuan Tradisional Untuk Pengobatan Diabetes Mellitus, cetakan X. Penebar Swadaya, Jakarta, 3-15.

Eleazu, C.O., Okafor, P.N., Ahamefuna, I., 2010. Total Antioxidant Capacity, Nutritional Composition and Inhibitory Activity of Unripe Plantain (Musa paradisiaca) on Oxidative Stress in Alloxan Induced Diabetic Rabbits. Pakistan Journal of Nutrition, 9 (11), 1052-1057.

Hiswani, 2011. Penyuluhan Kesehatan Pada Penderita Diabetes Mellitus, Fakultas Kedokteran Universitas Sumatra Utara, Medan.

Kaimal, S., Sujatha, K.S., George, S., 2010. Hypolipidaemic and Antioxidant Effects of Fruits of Musa AAA (Chenkadali) in Alloxan Induced Diabetic Rats (Ed 48), Indian Journal of Experimental Biology, 165-173.

Mayes, P.A., Murray, R., K., Granner, D., K., 2000. Harpers Biochemistry, 25th, edition, New York: Mc Graw-Hill, 7-10.

Nakanishi, K., 1974. Natural Products Chemistry, vol 1. Kodansha Scientific, Tokyo.

Nurmaulawati, R., 2004. Pengaruh Pemberian Fraksi Larut Air Ekstrak Etanolik Pisang Kapas (Musa paradisiaca L.) Terhadap Kadar Glukosa Darah Tikus Putih Jantan Galur Wistar (Rattus norvegicus) yang Dibebani Glukosa, Skripsi, Fakultas Farmasi, Univeristas Gajah Mada, Yogyakarta.

Suyono, S., 2002. Patofisiologi Diabetes Mellitus, cetakan ke 2, Fakultas Kedokteran Universitas Indonesia, Jakarta, 7-15.

Wells, B.G., Dipiro, J.T., Schwinghammer, T.L, Dipiro, C.V., 2009. Pharmacotherapy. Handbook, 7Th edition, Mc Graw Hill, New York

Zafar, M.I., Akter, S., 2011. Musa paradisiaca L. and Musa sapientum L.: A Phytochemical and Pharmacological Review. Journal of Applied Pharmaceutical Science, 01(05), 14-20.

DOI: https://doi.org/10.24071/jpsc.00123