Analysis of the Relationship Between Providing Drug Information, Medication Adherence, and Glycemic Control in Type 2 Diabetes Outpatients at the North Denpasar Health Center

Pande Made Desy Ratnasari(1*), Agustina Nila Yuliawati(2), Anak Agung Ngurah Putra Riana Prasetya(3), Ni Luh Koming Krisnamahesswari(4),

(1) Universitas Pendidikan Nasional
(2) Universitas Pendidikan Nasional
(3) Universitas Pendidikan Nasional
(4) Sekolah Tinggi Farmasi Mahaganesha
(*) Corresponding Author

Abstract


Medication adherence among patients with type 2 diabetes mellitus (T2DM) continues to be a difficult challenge. Providing drug information (PDI) at health centers can enhance medication adherence and help patients achieve glycemic control. A cross-sectional study was conducted in February-April 2024 at the North Denpasar Health Center. Inclusion criteria were patients >18 years old either with or without comorbidities, receiving the same antidiabetic treatment for ≥3 months. Exclusion criteria were patients who withdrew from the study, changed their care, or had unstable health conditions. Medication adherence data were collected using the Probabilistic Medication Adherence Scale (ProMAS) questionnaire, PDI data and fasting blood glucose (FBS) examination results in medical records using data collection documents. Correlation analysis between PDI and medication adherence and glycemic control used the Kendall's tau-b/c test. Results showed patients were mostly male (53.84%), age ≥65 (43.20%), elementary school education (35.50%), unemployed (63.90%), no family history (70.41%), disease duration <5 years (62.72%), with comorbidities (65.09%), and FBS achieved (81.66%). The antidiabetic used was a combination of metformin and glimepiride (54.43%). A total of 81.65% obtained routine PDI with high medication adherence (48.52%). The conclusion of the study was that there was a significant relationship between PDI with medication adherence (p=0.000; r=0.253) and glycemic control (p=0.000; r=0.447).

Keywords


Glycemic control; Medication adherence; Providing drug information; Type 2 diabetes mellitus

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References


Aguado, A., Moratalla-Navarro, F., López-Simarro, F., Moreno, V., 2020. MorbiNet: Multimorbidity networks in adult general population. Analysis of type 2 diabetes mellitus comorbidity. Scientific Reports, 10(1), 2416.

Alaqil, A., Alkahtani, M., Algahtani, M., 2020. Prevalence and predictors of glycemic control in hospitalized patients with diabetes. Indian Journal of Public Health Research & Development, 11(11), 409-415.

Almira, N., Arifin, S., Rosida, L., 2019. Faktor-faktor yang berhubungan dengan perilaku kepatuhan minum obat anti diabetes pada penderita diabetes melitus tipe 2 di Puskesmas Teluk dalam Banjarmasin. Homeostasis, 2(1), 9–12.

Alrashed, F., Ahmad, T., Almurdi, M., Alderaa, A., Alhammad, S., Serajuddin, M., Alsubiheen, A., 2024. Incorporating technology adoption in medical education: A qualitative study of medical students’ perspectives. Advances in Medical Education and Practice, 15, 615–625.

American Diabetes Association, 2023. Standards of care in diabetes. The Journal of Clinical and Aplied Research and Education, 46.

Anggriani, A., Yusrini Djabir, Y., Hakim, N., Atifah Ananda Usman, S., Kunci, K., Informasi Obat, P., Makassar, K., 2022. Penerapan Pelayanan Informasi Obat di Beberapa Puskesmas Kota Makassar. Original Article MFF, 26(3).

Anshari, A.F., Ichsan, B., Cholisoh, Z., 2023. Hubungan kepatuhan minum obat terhadap HbA1C dan kualitas hidup pasien diabetes di RSI Purwodadi. JPSCR: Journal of Pharmaceutical Science and Clinical Research, 8(3), 317.

Arania, R., Triwahyuni, T., Prasetya, T., Cahyani, S.D., 2021. Hubungan antara pekerjaan dan aktivitas fisik dengan kejadian diabetes mellitus di Klinik Mardi Waluyo Kabupaten Lampung Tengah. Jurnal Medika Malahayati, 5(3), 163–169.

Araswati, F., 2022. Pengaruh Pelayanan Informasi Obat (PIO) terhadap kepatuhan, pengetahuan, dan clinical outcome pasien diabetes melitus tipe 2 di Puskesmas Andalas Padang. Universitas Andalas.

Arifin, H., Kardela, W., Hafizah, H., 2020. Studi cross sectional pelayanan informasi obat diabetes melitus tipe 2 terhadap keberhasilan terapi pasien usia lanjut di rawatan Inap penyakit dalam RSUP Dr. M. Djamil Padang. Jurnal Farmasi Higea, 12(1).

Bahadoran, Z., Mirmiran, P., Kashfi, K., Ghasemi, A., 2023. Vascular nitric oxide resistance in type 2 diabetes. Cell Death & Disease, 14(7), 410.

Bidulang, C.B., Wiyono, W.I., Mpila, D.A., 2021. Evaluasi tingkat kepatuhan penggunaan obat antidiabetika pada pasien diabetes melitus tipe 2 di Puskesmas Enemawira. Pharmacon, 10, 1066–1070.

Cicek, M., Buckley, J., Pearson-Stuttard, J., Gregg, E.W., 2021. Characterizing multimorbidity from type 2 diabetes. Endocrinology and Metabolism Clinics of North America, 50(3), 531–558.

Dalal, J., Chandra, P., Chawla, R., Kumar, V., Abdullakutty, J., Natarajan, V., Naqvi, S.M.H., Gaurav, K., Rathod, R., Dhanaki, G., Kotak, B., Shah, S., 2024. Clinical and demographic characteristics of patients with coexistent hypertension, type 2 diabetes mellitus, and dyslipidemia: A retrospective study from India. Drugs - Real World Outcomes, 11(1), 167–176.

David, E.A., Soremekun, R.O., Abah, I.O., Aderemi-Williams, R.I., 2021. Impact of pharmacist-led care on glycaemic control of patients with uncontrolled type 2 diabetes: A randomised controlled trial in Nigeria. Pharmacy Practice, 19(3).

Denpasar City Health Office, 2023. Profil Dinas Kesehatan Kota Denpasar Tahun 2022. Denpasar.

Ernawati, D.A., Harini, I.M., Gumilas, N.S.A., 2020. Faktor-faktor yang mempengaruhi tingkat kepatuhan diet pada pasien diabetes melitus tipe 2 di Kecamatan Sumbang Banyumas. Journal of Bionursing, 2(1), 63–67.

Fitria, N., Anggraini, L. F., Sari, Y. O. 2023. Cost-effectiveness analysis of the combination of metformin-insulin glargine and metformin-glimepiride in type 2 diabetes mellitus patients in Rupit Hospital. Journal of Health Economic and Policy Research. 1. 1.

Gebermariam, A.D., Tiruneh, S.A., Ayele, A.A., Tegegn, H.G., Ayele, B.A., Engidaw, M., 2020. Level of glycemic control and its associated factors among type II diabetic patients in Debre Tabor General Hospital, Northwest Ethiopia. Metabolism Open, 8, 100056.

Geng, T., Zhu, K., Lu, Q., Wan, Z., Chen, X., Liu, L., Pan, A., Liu, G., 2023. Healthy lifestyle behaviors, mediating biomarkers, and risk of microvascular complications among individuals with type 2 diabetes: A cohort study. PLoS Medicine, 20(1), e1004135.

Hagi, K., Kochi, K., Watada, H., Kaku, K., Ueki, K., 2023. Effect of patient characteristics on the efficacy and safety of imeglimin monotherapy in Japanese patients with type 2 diabetes mellitus: A post‐hoc analysis of two randomized, placebo‐controlled trials. Journal of Diabetes Investigation, 14(9), 1101–1109.

Hatmawan, A., Riyanto, S., 2020. Metode Riset Penelitian Kuantitatif Penelitian di Bidang Manajemen, Teknik, Pendidikan dan Eksperimen. CV Budi Utama, Sleman.

Hayashino, Y., Izumi, K., Okamura, S., Nishimura, R., Origasa, H., Tajima, N., 2017. Duration of diabetes and types of diabetes therapy in Japanese patients with type 2 diabetes: The Japan Diabetes Complication and its Prevention prospective study 3 (JDCP study 3). Journal of Diabetes Investigation, 8(2), 243–249.

Hestiana, D. W. 2017. Faktor-faktor yang berhubungan dengan kepatuhan dalam pengelolaan diet pada pasien rawat jalan diabetes mellitus tipe 2 di Kota Semarang. JHE (Journal of Health Education), 2(2), 137-145.

Hu, Y., Zhang, X., Ma, Y., Yuan, C., Wang, M., Wu, K., Tabung, F.K., Tobias, D., Hu, F.B., Giovannucci, E., Song, M., 2021. Incident type 2 diabetes duration and cancer risk: A prospective study in two US cohorts. JNCI: Journal of the National Cancer Institute, 113(4), 381–389.

Huang, J., Ding, S., Xiong, S., Liu, Z., 2021. Medication adherence and associated factors in patients with type 2 diabetes: A structural equation model. Frontiers in Public Health, 9.

Husna, A., Jafar, N., Hidayanty, H., M.Dachlan, D., Salam, A., 2022. Hubungan kepatuhan minum obat dengan gula darah pasien DM tipe II di Puskesmas Tamalanrea Makassar. The Journal of Indonesian Community Nutrition, 11, 20–25.

International Diabetes Federation, 2021. International Diabetes Federation Diabetes Atlas, 10th edition. Brussels, Belgium.

Jasmine, N.S., Wahyuningsih, S., Thadeus, M.S., 2020. Analisis faktor tingkat kepatuhan minum obat pasien diabetes melitus di Puskesmas Pancoran Mas periode Maret-April 2019. Jurnal Manajemen Kesehatan Indonesia, 8(1).

Jumrotul, A., Wulan, N., Ainun, M., Permadi, Y., 2023. Pengaruh pelayanan informasi obat leaflet terhadap tingkat kepatuhan pasien diabetes mellitus kelas Prolanis Puskesmas Wonokerto 1. Prosiding Seminar Nasional UNIMUS, 6(18).

Khairinnisa, A., Yusmaini. H., Hadiwiardjo, Y. H. 2020. Perbandingan penggunaan glibenclamid-metformin dan glimepirid-metformin terhadap efek samping hipoglikemia pasien diabetes melitus tipe-2 di Kota Tangerang Selatan bulan Januari-Oktober Tahun 2019. In: Seminar Nasional Riset Kedokteran (SENSORIK) 2020. p. 147.

Kleppe, M., Lacroix, J., Ham, J., Midden, C., 2015. The development of the ProMAS: A probabilistic medication adherence scale. Patient Preference and Adherence, 9.

Kurniati, M.F., Abidin, A.Z., Kasini, 2023. Hubungan kepatuhan kontrol dengan kadar gula darah puasa pasien diabetes mellitus di Puskesmas Ngraho. Jurnal Ilmu Kesehatan MAKIA, 13(1).

Lailaturrahmi, L., Araswati, F., Armenia, A., Yosmar, R., 2022. Effect of drug information service on clinical outcome of patients with type 2 diabetes mellitus in Padang, Indonesia. Borneo Journal of Pharmacy, 5(2), 186–193.

Liao, Y.-S., Tsai, W.-C., Chiu, L.-T., Kung, P.-T., 2023. Educational attainment affects the diagnostic time in type 2 diabetes mellitus and the mortality risk of those enrolled in The Diabetes Pay-For-Performance Program. Health Policy, 138, 104917.

Listyana, Y.I., Yasin, N.M., Andayani, T.M., 2021. Persepsi sakit dan outcome klinik pasien diabetes melitus pada pelayanan berbasis medication therapy management. Journal of Management and Pharmacy Practice, 11(2).

Ministry of Health, 2016. Standar Pelayanan Kefarmasian Di Puskesmas, Kementerian Kesehatan Republik Indonesia. Indonesia.

Nanda, O.D., Wiryanto, B., Triyono, E.A., 2018. Hubungan kepatuhan minum obat anti diabetik dengan regulasi kadar gula darah pada pasien perempuan diabetes mellitus. Amerta Nutrition, 2(4), 340.

Nordstrom, A., Hadrevi, J., Olsson, T., Franks, P.W., Nordstrom, P., 2016. Higher prevalence of type 2 diabetes in men than in women is associated with differences in visceral fat mass. The Journal of Clinical Endocrinology & Metabolism, 101(10), 3740–3746.

Nuraini, A., Rahayu, D., Rokhani, R., Sa’diyah, H., Aristia, B.F., Ningsih, A.W., 2023. Evaluasi pelayanan informasi obat pada pasien rawat jalan di Puskesmas X Kabupaten Bangkalan. Indonesian Journal of Pharmaceutical Education (e-Journal), 3(3).

Pham, N.M., Eggleston, K., 2016. Prevalence and determinants of diabetes and prediabetes among Vietnamese adults. Diabetes Research and Clinical Practice, 113, 116–124.

Pharamita, A., 2023. Hubungan tingkat pengetahuan dengan kepatuhan minum obat pada pasien diabetes melitus di wilayah kerja Puskesmas Sumurgung. Jurnal Multidisiplin Indonesia, 2(9), 2859–2868.

Pramestyani, E.D., Ratnasari, D., Panduwiguna, I., 2023. Evaluasi pelayanan informasi obat di instalasi farmasi rawat jalan UPTD Puskesmas Ciasem Kabupaten Subang. Jurnal Farmasi Kryonaut, 2(2), 14–18.

Pratiwi, C., Rumende, M., Kshanti, I.A.M., Soewondo, P., 2022. Risk factors for inpatient hypoglycemia in a tertiary care hospital in Indonesia. Journal of the ASEAN Federation of Endocrine Societies, 37(2), 28–33.

Putri, J.P., 2020. Pengaruh Pemberian Informasi Obat Dengan Media Video Terhadap Kepatuhan Minum Obat Pasien Diabetes Melitus Tipe 2 Di Puskesmas Ungaran. Universitas Ngudi Waluyo.

Rahmawati, D.A., Widayanti, MPH., Apt., Ph.D., A.W., Kristina, S.A., 2023. Measurement of medication adherence behavior in type 2 diabetes mellitus patients using Probabilistic Medication Adherence Scale (ProMAS). Journal of Management and Pharmacy Practice, 13(3).

Rahmawaty, A., Anggraeni, N.W., 2023. Pengaruh konseling apoteker terhadap kepatuhan penggunaan obat dan kontrol glikemik pasien DM tipe 2 pada Program Rujuk Balik BPJS Kesehatan di Puskesmas Kota Bandung. Jurnal Riset Kefarmasian Indonesia, 5(1), 181–193.

Rikesdas, 2019. Laporan Nasional Riset Kesehatan Dasar 2018. Jakarta.

Santosa, A., Trijayanto, P.A., Endiyanto, 2017. Hubungan riwayat garis keturunan dengan usia terdiagnosis diabetes melitus tipe II. Jurnal Ilmiah Kesehatan, Universitas Muhammidiyah Magelang, The 6th University Research Colloquium 2017.

Santoso, S.A., Setiadi, A.P., Widjaja, K.K., Wibowo, Y.I., 2023. Drug information for diabetes mellitus outpatients at RSUD X Surabaya: What was provided and what was known? Jurnal Ilmu Kefarmasian Indonesia, 21(1), 27.

Sendekie, A.K., Netere, A.K., Kasahun, A.E., Belachew, E.A., 2022. Medication adherence and its impact on glycemic control in type 2 diabetes mellitus patients with comorbidity: A multicenter cross-sectional study in Northwest Ethiopia. PLoS ONE, 17(9), e0274971.

Shuvo, S. Das, Hossen, M.T., Riazuddin, M., Hossain, M.S., Mazumdar, S., Parvin, R., Elahi, M.T., 2023. Prevalence of comorbidities and its associated factors among type-2 diabetes patients: A hospital-based study in Jashore District, Bangladesh. BMJ Open, 13(9), e076261.

Song, Z., Yang, R., Wang, W., Huang, N., Zhuang, Z., Han, Y., Qi, L., Xu, M., Tang, Y., Huang, T., 2021. Association of healthy lifestyle including a healthy sleep pattern with incident type 2 diabetes mellitus among individuals with hypertension. Cardiovascular Diabetology, 20(1), 239.

Rusdi, M.S., 2020. Hipoglikemia pada pasien diabetes melitus. Journal Syifa Sciences and Clinical Research, 2(2).

Trerattanavong, K., Tadi, P., 2021. Glimepiride. [WWW Document]. Towards Data Science. URL https://www.ncbi.nlm.nih.gov/books/NBK554600 (accessed 30.09.21).

Triastuti, N., Irawati, D.N., Levani, Y., Lestari, R.D., 2020. Faktor yang mempengaruhi tingkat kepatuhan konsumsi obat antidiabetes oral pada pasien diabetes melitus tipe 2 di RSUD Kabupaten Jombang. Medica Arteriana (Med-Art), 2(1), 27.

Wishesa, C.C., Kamil, A.S.I., 2023. Gambaran kepatuhan pengobatan pasien diabetes di Puskesmas Kedurus pada era pandemi COVID-19. Preventif : Jurnal Kesehatan Masyarakat, 14(1).

Yimam, M., Desse, T.A., Hebo, H.J., 2020. Glycemic control among ambulatory type 2 diabetes patients with hypertension co-morbidity in a developing country: A cross sectional study. Heliyon, 6(12), e05671




DOI: https://doi.org/10.24071/jpsc.009708

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