The Analysis of Medicine-taking Compliance Towards Therapy Outcome in Hypertension Patients at Community Health Centers in Yogyakarta Municipality

Rimanita Fortinasari; Dita Maria Virginia; Phebe Hendra

doi:10.24071/jpsc.008656

The Analysis of Medicine-taking Compliance Towards Therapy Outcome in Hypertension Patients at Community Health Centers in Yogyakarta Municipality

Rimanita Fortinasari^(1*), Dita Maria Virginia⁽²⁾, Phebe Hendra⁽³⁾,

(1) Sanata Dharma University
(2) Faculty Pharmacy, Universitas Sanata Dharma
(3) Faculty Pharmacy, Universitas Sanata Dharma
(*) Corresponding Author

Abstract

Compliance to medication has a significant role in regulating the blood pressure and the risk for Atherosclerosis Vascular Disease (ASCVD) in Diabetes Mellitus Type 2 (DMT2) patients with hypertension as comorbidity. This study (n=523) aimed to analyzed this relationship at community health centers Yogyakarta municipality. We conducted an observational study with a cross-sectional design to analyze the medical record data collected during January-December 2023 among patients categorized under the inclusion criteria. Compliance was measured using the Medication Possession Ratio (MPR) then descriptively and correlatively with Chi-square analyses. No significant relationship is showed between the compliance of antihypertensive therapy to blood pressure (p=0.867>0.05) and ASCVD risk (p=0.080>0.05; OR=0.662; 95%CI:0.416-1.052). Age (p=<0.001), gender (p=<0.001) and BMI (p=0.0014) had a highly significant relationship with ASCVD risk, but only BMI (p=0.007<0.005; OR 1.812) showed significant relationship with controlled blood pressure. The research findings reveal that compliance to antihypertensive therapy does not have a significant relationship with blood pressure control or ASCVD risk in patients with DMT2 and hypertension as comorbidities in Yogyakarta municipality. Highlighting the need for further investigation, it is vital to include other factors into blood pressure management.

Keywords

ASCVD risk; Blood pressure; Compliance; Diabetes mellitus; Municipality health clinic

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References

Anharudin, and Tejamaya, M. 2022. Comparison of cardiovascular risk using the Framingham Method, WHO Chart and ASCVD in PT. X Year 2021. Promotif : Jurnal Kesehatan Masyarakat, 12(1), 77–85.

Appelman, Y., van Rijn, B. B., ten Haaf, M. E., Boersma, E., and Peters, S. A. E., 2014. Sex differences in cardiovascular risk factors and disease prevention. Atherosclerosis, 241(1), 211–218.

Aronow, W. S., and Shamliyan, T. A., 2018. Blood pressure targets for hypertension in patients with type 2 diabetes. Annals of Translational Medicine, 6(11), 199–199.

Asseggaf, S. N. Y. R. S., and Ulfah, R., 2022. Analisa kepatuhan minum obat antihipertensi pada pasien peserta Posyandu Lansia Kartini Surya Khatulistiwa Pontianak. Jurnal Pharmascience, 9(1), 48–59.

Azmi, R. N., Lestari, D., Urahman, D., and Tifana, S., 2021. Hubungan kepatuhan minum obat dengan outcome therapy antihipertensi pada geriatrik di panti sosial tresna werdha nirwana puri Samarinda. Jurnal Farmagazine, 8(2), 8–13.

Calisanie, N. N. P., Susanti, S., and Lindayani, L. 2020. Cardiovascular risk estimation in patients with hypertension: A cross-sectional study. Jurnal Ners, 15(1), 98–104.

Christiyani, N.C., Marlina, T.T, and Estri, A.K., 2023. Hubungan tingkat pengetahuan dengan kepatuhan minum obat pada pasien hipertensi di Yogyakarta. CARING, 7(1), 18–27.

Derington, C. G., King, J. B., Herrick, J. S., Shimbo, D., Kronish, I. M., Saseen, J. J., Muntner, P., Moran, A. E., and Bress, A. P., 2020. Trends in antihypertensive medication monotherapy and combination use among US adults: National Health and Nutrition Examination Survey 2005–2016. AHA Journal, 973–981.

Dinas Kesehatan Kota Yogyakarta. 2023. Profil Kesehatan Kota Yogyakarta 2023. 152–153.

Dwivani, C., Harijadi, K., and Suhadi, R., 2018. Perbandingan lima metode estimasi risiko 10 tahun penyakit kardiovaskuler pada masyarakat kabupaten Sleman-Yogyakarta [Comparison five methods of 10 years cardiovascular disease risk estimation among community in Sleman-Yogyakarta.] JMPF, 8(2), 59–69.

Egan, B. M., Sutherland, S. E., Rakotz, M., Yang, J., Bruce Hanlin, R., Davis, R. A., and Wozniak, G., 2018. Improving hypertension control in primary care with the measure accurately, act rapidly, and partner with patients’ protocol results at 6 and 12 months. Hypertension, 72(6), 1320–1327.

Framingham Heart Study. (n.d.). Cardiovascular Disease (10-year risk). Retrieved March 17, 2024, from https://www.framinghamheartstudy.org/fhs-risk-functions/cardiovascular-disease-10-year-risk/

Hendra, P., Setiawan, C. H., Virginia, D. M., and Julianus, J., 2022. Keberhasilan Terapi pada Pasien Risiko Kardiovaskular (Z. D. Pramono, Ed.; 1st ed.). Sanata Dharma University Press.

Husna, N., Sugiyono, and Yunilistianingsih., 2023. The analysis of knowledge, adherence, and clinical outcome of hypertensive patients in Puskesmas Jetis Yogyakarta. Jurnal Ilmu Kefarmasian Indonesia, 21(1), 1–6.

Kementerian Kesehatan Republik Indonesia 2019. Retrieved Mei 01, 2024. https://p2ptm.kemkes.go.id/infographicp2ptm/obesitas/tabel-batas-ambang-indeks-massa-tubuh-imt

Khomaini, A., Setiati, S., Lydia, A., and Dewiasty, E., 2017. The effect of structured education and antihypertensive medications adherence to decrease blood pressure for hypertension in elderly: A randomized controlled trial. Jurnal Penyakit Dalam Indonesia, 4(1).

Kurniawan, A. H., Suwandi, B. H., Prakoso, D. T., Moksidy, R. C., Talitha, I., Anggraeni, M. K., and Zulkifli, D., 2021. Correlation between body mass index to hypertension in a rural area in East Java. Mutiara Medika: Jurnal Kedokteran Dan Kesehatan, 21(1), 26–31.

Lukito, A. A., Harmeiwaty, E., and Hustrini, N. M., 2019. Konsensus Penatalaksanaan Hipertensi Inash. Perhimpunan Dokter Hipertensi Indonesia, 1–118.

Maharani, A., Sujarwoto, Praveen, D., Oceandy, D., Tampubolon, G., and Patel, A., 2019. Cardiovascular disease risk factor prevalence and estimated 10-year cardiovascular risk scores in Indonesia: The SMARThealth Extend study. PLoS ONE, 14(4).

Muiesan, M. L., Salvetti, M., Rosei, C. A., and Paini, A. 2016. Gender differences in antihypertensive treatment: Myths or legends? High Blood Pressure and Cardiovascular Prevention, 23(2), 105–113.

Nagao, T., Nogawa, K., Sakata, K., Morimoto, H., Morita, K., Watanabe, Y., and Suwazono, Y. 2021. Effects of alcohol consumption and smoking on the onset of hypertension in a long-term longitudinal study in a male workers’ cohort. International Journal of Environmental Research and Public Health, 18(22), 1–11.

Natekar, A., Olds, R. L., Lau, M. W., Min, K., Imoto, K., and Slavin, T. P. 2014. Elevated blood pressure: Our family’s fault? The genetics of essential hypertension. World Journal of Cardiology, 6(5), 327–337.

Rajendran, A., Minhas, A. S., Kazzi, B., Varma, B., Choi, E., Thakkar, A., and Michos, E. D. 2023. Sex-specific differences in cardiovascular risk factors and implications for cardiovascular disease prevention in women. In Atherosclerosis (Vol. 384). Elsevier Ireland Ltd.

Rasdianah, N., Martodiharjo, S., Andayani, T. M., and Hakim, L. 2016. The description of medication adherence for patients of diabetes mellitus type 2 in public health center Yogyakarta. Indonesian Journal of Clinical Pharmacy, 5(4), 249–257.

Saputri, Z. G., Akrom, A., and Darmawan, E. 2016. Tingkat kepatuhan antihipertensi dan pengontrolan tekanan darah pasien rawat jalan RS PKU Muhammadiyah Bantul, Yogyakarta yang mendapatkan brief counseling-5A dan SMS motivasional. Journal of Pharmaceutical Sciences and Community, 13(02), 67–72.

Setiawan, C. H., Hendra, P., Virginia, D. M., and Sari, L. K., 2022. Influence of therapy compliance using medication possession ratio method for patients with metabolic syndrome. Indonesian Journal of Clinical Pharmacy, 11(2), 145–154.

Sihombing, M. 2017. Faktor yang Berhubungan dengan Hipertensi pada Penduduk Indonesia yang Menderita Diabetes Melitus (Data Riskesdas 2013). Buletin Penelitian Kesehatan, 45(1).

Soelistijo, S. A., Suastika, K., Lindarto, D., and Decroli, E., 2021. Pedoman Pengelolaan Dan Pencegahan Diabetes Melitus Tipe 2 Dewasa Di Indonesia (Vol. 2).

Srikartika, V. M., Dwi Cahya, A., and Hardiati, R. S. W. 2016. Analisis Faktor Yang Mempengaruhi Kepatuhan Penggunaan Obat Pasien Diabetes Melitus Tipe 2. Jurnal Manajemen Dan Pelayanan Farmasi, 6(3), 205–212.

Suhadi, R., Hendra, P., Wijoyo, Y., Virginia, D. M., and Setiawan, C. H. 2016. Seluk Beluk Hipertensi: Peningkatann Kompetensi Klinis untuk Pelayanan Kefarmasian (P. Baryadi, Ed.; 1st ed.). Sanata Dharma University Press.

Vusvitasari, R., Nugroho, S., and Akbar, D. S., 2008. Kajian Hubungan Koefisien Korelasi Pearson (r), Spearman-Rho (ρ), Kendall-Tau (τ), Gamma (G), dan Somers. Jurnal Gradien, 4, 40–54.

DOI: https://doi.org/10.24071/jpsc.008656