Health Related Quality of Life (HRQoL) in Type 2 Diabetes Mellitus Patients Based on Antidiabetic Prescription Patterns

Seftika Sari; Erniza Pratiwi; Dinda Farahdilla; MT Ghozali; Indriyati Hadi Sulistyaningrum; Prasojo Pribadi

doi:10.24071/jpsc.008444

Health Related Quality of Life (HRQoL) in Type 2 Diabetes Mellitus Patients Based on Antidiabetic Prescription Patterns

Seftika Sari^(1*), Erniza Pratiwi⁽²⁾, Dinda Farahdilla⁽³⁾, MT Ghozali⁽⁴⁾, Indriyati Hadi Sulistyaningrum⁽⁵⁾, Prasojo Pribadi⁽⁶⁾,

(1) Sekolah Tinggi Ilmu Farmasi Riau
(2) Sekolah Tinggi Ilmu Farmasi Riau
(3) Sekolah Tinggi Ilmu Farmasi Riau
(4) Universitas Muhammadiyah Yogyakarta
(5) Universitas Islam Sultan Agung
(6) Universitas Muhammadiyah Magelang
(*) Corresponding Author

Abstract

Diabetes mellitus is characterized as a multifaceted metabolic disorder marked by elevated blood sugar levels or hyperglycemia. Among its types, type 2 diabetes mellitus is the most common globally, significantly affecting a large portion of the population. In Indonesia, there has been a notable increase in the prevalence of type 2 diabetes, indicating a rising trend. This condition necessitates continuous care and management since it is incurable, requiring patients to undergo lifelong treatment. The various therapeutic approaches available for managing type 2 diabetes have a significant impact on the quality of life of patients, highlighting the necessity for quality-of-life assessments. The primary objective of this study was to assess the quality of life among individuals diagnosed with type 2 diabetes mellitus. It also aimed to investigate the effects of different patterns of antidiabetic drug prescriptions on the Health-Related Quality of Life (HRQoL), employing the Diabetes Quality of Life Clinical Trial Questionnaire (DQLCTQ) for evaluation. This study was conducted as a quantitative, observational research using a cross-sectional approach and a descriptive analytical method. A total of 99 participants were included through purposive sampling, a non-probability sampling technique. The findings showed that the average quality of life score was 70.56, with 48 participants (48.5%) reported to have a good quality of life and 51 (51.5%) considered to have a poor quality of life. Importantly, significant results (p<0.05) were found regarding the positive effects of combining oral antidiabetic drugs with insulin on enhancing the quality of life in individuals with type 2 diabetes, underscoring the influence of medication regimens on patient health outcomes.

Keywords

Health related quality of life (HRQoL); Pattern of antidiabetic prescribing; Type 2 diabetes mellitus

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References

Alsheed, A. H., Constantino, M. I., Molyneaux L., D’Shouza, M., Gisler, F.L., Luo, C., Wu, Ted., Twigg, S. M., Yue, D. K., and Wong, J. 2016. An Inverse Relationship Between Age of Type 2 Diabetes Onset and Complication Risk and Mortality: The Impact of Youth-Onset Type 2 Diabetes. Diabetes Care, 39(5),1-7.

American Diabetes Association. 2018a. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care. 41(1),73-85.

American Diabetes Association. 2018b. Standar of Medical Care in Diabetes- 2018. Clin Diabetes, 36(1),14-37.

Davies, M.J., Alessio, D. A. D., Fradkin, J., Kernan, W, N., Mathieu, C., Mingrone, G., Rossing, P., Tsapas, A., Wexler, D. J. and Buse, J. B. 2018. Management of Hyperglycaemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care, 41(12), 2669-2701.

Dipiro, C. V., Schwinghammer, T.L., Wells, B.G. and Dipiro, J.T. 2016. Pharmacotherapy Handbook. Inggris: McGraw-Hill Education Companies.

Fatima, M., Sadeeqa, S. and Nazir, S. U. R. 2018. Metformin and Its Gastrointestinal Problems: A Review. Biomed Research, 29(11), 2285-2289.

Fatimah, R. N. 2015. Diabetes Melitus Tipe 2. Majority, 4(5), 93-99.

Gao, X., Cai, X., Yang, W., Chen, Y., Han, X. and Ji, L. 2018. Meta-analysis and Critical Review on The Efficacy and Safety of Alpha-glucosidase Inhibitors in Asian and Non-Asian Populations. Journal of Diabetes Investigation, 9(2), 321-331.

Gregg, E. W. 2017. The Changing Tides of the Type 2 Diabetes Epidemic-Smooth Sailing or Troubled Waters Ahead? Kelly West Award Lecture 2016. Diabetes Care, 40, 1289-1297.

Hayek, A. A. A., Robert, A. A., Saeed, A. A., Alzaid, A. A. and Sabaan, F. S. A. 2014. Factors Associated with Health-Related Quality of Life among Saudi Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Survey. Diabetes & Metabolism Journal, 38, 220-229.

Hestiana, D. W. 2017. Faktor-Faktor yang Berhubungan dengan Kepatuhan dalam Pengelolaan Diet pada Pasien Rawat Jalan Diabetes Mellitus Tipe 2 di Kota Semarang. Journal of Health Education, 2(2), 138-145.

Imelda, S. 2019. Faktor-Faktor yang Mempengaruhi Terjadinya Diabetes Melitus di Puskesmas Harapan Raya Tahun 2018. Scientia Journal, 8(1), 28-39.

International Diabetes Federation. 2017. IDF Diabetes Atlas Eighth Edition. IDF. Belgia.

Inzucchi, S. E., Bergenstal, R. M., Buse, J. B., Diamant, M., Ferrannini, E., Nauck, M., Peters, A. L., Tsapas, A., Wender, R. and Matthews, D. R. 2015. Management of Hyperglycemia in Type 2 Diabetes, 2015: A PatientCentered Approach: Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care, 38(1),140-149.

Isnaini, N. and Ratnasari, R. 2018. Faktor Risiko Mempengaruhi Kejadian Diabetes Mellitus Tipe Dua. Jurnal Kebidanan dan Keperawatan Aisyiyah, 14(1), 59-68.

Jelantik, I. M. and Haryati, E. 2014. Hubungan Faktor Resiko Umur, Jenis Kelamin, Kegemukan dan Hipertensi dengan Kejadian Diabetes Melitus Tipe II di Wilayah Kerja Puskesmas Mataram. Jurnal Media Bina Ilmiah, 8(1), 39.

Laoh, J., and Tampongangoy, D. 2015. Gambaran Kualitas Hidup Pasien Diabetes Melitus di Poliklinik Endokrin RSUP Prof. Dr. R. D. Kandou Manado. Juiperido, 4(1), 32-37.

Madelina, W., Untari, K. E., and Nansy, E. 2018. Efek Perseptif Penggunaan Kombinasi Antidiabetes Oral-Insulin pada Pasien Diabetes Melitus Tipe 2 di Kota Pontianak Sekitarnya. Jurnal Farmasi Klinik Indonesia, 7(3), 209-216.

Nugraha, R. P. 2021. Kualitas Hidup Pasien Diabetes Melitus Tipe 2 yang Mendapat Antidiabetika Oral di Puskesmas Kaliwungu Kabupaten Kudus dengan Menggunakan Kuesioner DQLCTQ. Skripsi. Universitas Islam Sultan Agung Semarang.

Ogurtsova, K., Fernandes, J. D. R., Huang, Y., Linnenkamp, U., Guariguata, L., Cho, N. H., Cavan, D., Shaw, J. E. and Makaroff, L. E. 2017. IDF Diabetes Atlas: Global Estimates for The Prevalence of Diabetes for 2015 and 2040. Diabetes Research and Clinical Practice, 128, 40-50.

Owens, D. R. 2013. Clinical Evidence for the Earlier Initiation of Insulin Therapy in Type 2 Diabetes. Diabetes Technology and Therapeutics, 15(9), 776-785.

Pasha, Y. M. dan Fatin, M. N. A. 2021. Analisis Faktor yang Mempengaruhi Kualitas Hidup Pada Pasien Prolanis (Program Pengelolaan Penyakit Kronis) Diabetes Melitus Tipe 2 di Beberapa Puskesmas Kota Bandung. Journal of Pharmacopolium, 4(2), 91-97.

Persaud, H. dan Williams, S. 2017. Occupational Stress and Increased Risk for Type 2-Diabetes: A New Narrative Review. Journal of Complementary Medicine and Alternative Healthcare, 2(5), 1-7.

Perwitasari, D. A., Adikusuma, W., Rikifani, S., Supadmi, W. dan Kaptein, A. A. 2014. Quality of Life and Adherence of Diabetic Patients in Different Treatment Regimens Kualitas Hidup dan Kepatuhan Pasien Diabetes Melitus dengan Pengobatan yang Berbeda. Indonesian Journal of Clinical Pharmacy. 3(4), 107-113.

Pratiwi, P., Amatiria, G., Yamin, M. 2014. Pengaruh Stress Terhadap Kadar Gula Darah Sewaktu Pada Pasien Diabetes Melitus yang Menjalani Hemodialisa. Jurnal Kesehatan. 1(4), 11-16.

Sepulveda, E., Poínhos, R., Constante, M., Pais-ribeiro, J., Freitas, P. and Carvalho, D. 2015. Health-related quality of life in type 1 and type 2 diabetic patients in a Portuguese central public hospital. Diabetes Metabolic Syndrome Obesity. 8, 219-226.

Shen, W., Kotsanos, J. G., Huster, W. J., Mathias, S. D., Andrejasich, C. M. and Patrick, D. L. 1999. Development and validation of the diabetes quality of life clinical trial questionnaire. Medical Care, 37(4), 45-66.

World Health Organization. 2014. World Health Statistics. WHO. Switzerland.

World Health Organization. 2016. World Health Statistics: Monitoring Health for The SDGs. WHO. Switzerland.

Yadav, M., Saraswat, N., Wal, P., Rai, A. K. and Singh, D. 2018. A Comparative Study of Drug Interaction and Side Effect of Drug for Treatment of Diabetes Mellitus: A Review. International Research Journal of Pharmacy, 9(6), 14-16.

Yuswar, M. A., Rizkifani, S., dan Sutanto, G. E. 2022. Kualitas Hidup Pasien Diabetes Melitus Tipe 2 di RSUD Syarif Mohamad Alkadrie Pontianak. Proceeding of Mulawarman Pharmaceuticals Conferences. 15(15), 218-222.

DOI: https://doi.org/10.24071/jpsc.008444