Gastroprotective Potential of Hantap Leaves (Sterculia coccinea Jack) Extract in Stress-Induced Gastric Ulcers of Male White Rats

Yuliet - Yuliet; Khildah Khaerati; Gladies Melinda Lokong

doi:10.24071/jpsc.006398

Gastroprotective Potential of Hantap Leaves (Sterculia coccinea Jack) Extract in Stress-Induced Gastric Ulcers of Male White Rats

Yuliet - Yuliet^(1*), Khildah Khaerati⁽²⁾, Gladies Melinda Lokong⁽³⁾,

(1) Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Tadulako University, Palu-94118, Central Sulawesi, Indonesia
(2) Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Tadulako University, Palu-94118, Central Sulawesi, Indonesia
(3) Laboratory of Pharmacology and Clinical Pharmacy, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Tadulako University, Palu-94118, Central Sulawesi, Indonesia
(*) Corresponding Author

Abstract

Stomach ulcer is a prevalent digestive problem that can lead to serious complications such as bleeding in the digestive tract, perforation, recurrence, cancer, and even death. One of its potential remedies lies in the antioxidant compounds contained in hantap leaves. Accordingly, this study aimed to investigate the anti-gastric ulcer effects of hantap leaf extract in white male rats induced by water immersion and cold-resistant stress methods. Hantap leaf extract (EEDH) was obtained by maceration using 96% ethanol, resulting in a yield of 7.8%. The results of gastric macroscopic observations based on percentage of ulcer inhibition showed that EEDH doses of 50, 100, and 200 mg/kg BW did not have a significant difference (p<0.05) with ranitidine, exhibiting the same gastroprotective effects. An increase in the dose does not lead to a corresponding rise in the gastroprotective effect. Therefore, 50 mg/kg BW of EEDH was considered to be the optimum dose.

Keywords

Gastric ulcer; Gastroprotective; Hantap leaves; Stress

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DOI: https://doi.org/10.24071/jpsc.006398