In Vitro and In Vivo Anti Hyperglycemic Evaluation of Sterculia quadrifida Bark through The Inhibition of Alpha Glucosidase

Jeffry Julianus; Maria Dewi Puspitasari Tirtaningtyas Gunawan-Puteri; Radhita Tyastu Puteri Wiwengku; Agustina Setiawati; Phebe Hendra

doi:10.24071/jpsc.005153

In Vitro and In Vivo Anti Hyperglycemic Evaluation of Sterculia quadrifida Bark through The Inhibition of Alpha Glucosidase

Jeffry Julianus⁽¹⁾, Maria Dewi Puspitasari Tirtaningtyas Gunawan-Puteri⁽²⁾, Radhita Tyastu Puteri Wiwengku⁽³⁾, Agustina Setiawati⁽⁴⁾, Phebe Hendra^(5*),

(1) Faculty of Pharmacy, Sanata Dharma University, Yogyakarta 55282, Indonesia
(2) Department of Food Technology, Swiss German University, Tangerang, Indonesia
(3) Faculty of Pharmacy, Sanata Dharma University, Yogyakarta 55282, Indonesia
(4) Faculty of Pharmacy, Sanata Dharma University, Yogyakarta 55282, Indonesia
(5) Faculty of Pharmacy, Sanata Dharma University, Yogyakarta 55282, Indonesia
(*) Corresponding Author

Abstract

Data from the International Diabetes Federation revealed annual increases in the prevalence of diabetes mellitus, which require special attention. Implementation of the ‘back to nature’ trend presents opportunities to overcome this problem. As a medicinal plant, Faloak is widely used by people in Nusa Tenggara Timur, Indonesia. This study aimed to evaluate in vivo and in vitro anti-hyperglycemic activity of the bark of Sterculia quadrifida, known as Faloak. In vivo evaluation used sucrose-induced male mice. Measurements of glucose level employed a glucometer and data were analyzed statistically. Demonstrating anti-hyperglycemic activity of the bark of Faloak decoct, results showed doses 1.67 and 3.3 g/kg BW reduced glucose levels by 62.2% and 56.9%, respectively. In vitro examination of Faloak decoct at various concentrations used alpha glucosidase (sucrose) enzymatic reaction. Results of in vitro examinations demonstrated of Faloak bark decoct inhibited alpha glucosidase (sucrose) activity by 42.09 ± 4.39%. Further testing on humans is needed to confirm these findings.

Keywords

Anti-hyperglycemic; alpha glucosidase inhibitor; Faloak; in vivo; in vitro

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DOI: https://doi.org/10.24071/jpsc.005153