PROFILE OF ANTICANCER ACTIVITIES OF BROTOWALI (Tinospora crispa L.)  PLANTS OFVARIOUS REGIONS IN EAST JAWA

Roihatul Mutiah; Laily Nurul Azizah; Rahmi Annisa; Anik Listyana

doi:10.24071/jpsc.002020

PROFILE OF ANTICANCER ACTIVITIES OF BROTOWALI (Tinospora crispa L.) PLANTS OFVARIOUS REGIONS IN EAST JAWA

Roihatul Mutiah^(1*), Laily Nurul Azizah⁽²⁾, Rahmi Annisa⁽³⁾, Anik Listyana⁽⁴⁾,

(1) Maulana Malik Ibrahim State Islamic University of Malang
(2) Maulana Malik Ibrahim State Islamic University of Malang
(3) Maulana Malik Ibrahim State Islamic University of Malang
(4) Maulana Malik Ibrahim State Islamic University of Malang
(*) Corresponding Author

Abstract

Brotowali (Tinosporacrispa L) is a plant which has potential to be a chemopreventive agent. This study aims to determine the profile of anticancer activity of brotowali stem extracts (Tinosporacrispa L.), from several regions in East Java. The extraction was carried out by maceration method using 80% ethanol solvent. Then, anticancer activity test was carried out on MCF-7 breast cancer cell model using the Microtetrazolium (MTT) Assay method. The results of the anticancer activity test showed that 15 brotowali stem extracts taken from 5 locations in East Java had significant differences in anticancer activity (P <0.05). Brotowali extracts from Kanigoro, Blitar city, had the highest anticancer activity with an IC₅₀value of 30.64 g / mL.

Keywords

anticancer profile; brotowali (Tinospora crispa L.); East Java; microtetrazolium (MTT) assay method

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DOI: https://doi.org/10.24071/jpsc.002020