COMPOUNDING STERILE PREPARATIONS FOR INTENSIVE CARE UNIT PATIENTS (ICU) IN ONE PRIVATE HOSPITAL IN SEMARANG

Sara Septi Widayani, Sri Hartati Yuliani, Dina Christin Ayuning Putri

Abstract


Sterile preparations for intravenous injection probably cause greater risk of errors than other preparation treatment routes due to their complex preparation steps. Errors in preparation and compounding stage will affect the quality and stability of the pharmaceutical product obtained. The aim of this study was to evaluate the process of compounding and assess both quality and stability of the parenteral preparations products that resulted from the compounding process for ICU’s patients in one private hospital in Semarang, Central Java, Indonesia. This observational analytic study was conducted using accidental sampling technique. The descriptive study results showed that sterile preparation in hospital “X” was not performed according to the Guidelines for Drug Injection and Handling of Cytostatic Preparations. In order to evaluate the quality of the sterile preparations, three different drugs with the highest prevalence of use: namely ceftriaxone, meropenem and omeprazole were evaluated. It was found that the pH value of omeprazole was not acceptable due to the use of an appropriateness solvent. The sterility tests showed that the preparation products prepared by the nurses were free from microorganisms.


Keywords


dispensing errors; intensive care unit; intravenous preparations; patient; sterile compounding

Full Text:

PDF

References


Agoes, G., 2009. Sediaan Farmasi Steril. Penerbit ITB, Bandung.

Agyemang, R.E.O., While, A., 2010. Medication errors: types, causes and impact on nursing practice. British Journal of Nursing, 19(6), 380–385.

Alhazzani, W., Alenezi, F., Jaeschke, R.Z., Moayyedi, P., Cook, D.J., 2013. Proton Pump Inhibitors Versus Histamine 2 Receptor Antagonists for Stress Ulcer Prophylaxis in Critically Ill Patients: A Systematic Review and Meta-Analysis*. Critical Care Medicine, 41(3), 693.

Amin, R., Gul, R., Mehrab, A., 2013. Hospital Waste Management. Professional Medical Journal, 20(6), 988–994.

Barkun, A.N., Bardou, M., Pham, C.Q.D., Martel, M., 2012. Proton Pump Inhibitors vs. Histamine 2 Receptor Antagonists for Stress-Related Mucosal Bleeding Prophylaxis in Critically Ill Patients: A Meta-Analysis. The American Journal of Gastroenterology, 107(4), 507–520.

Chartier, Y., 2014. Safe Management of Wastes from Health-care Activities. World Health Organization.

Collins, S., 2014. Preparation is critical to high-risk sterile compounding. Pharmacy Today, 20(7), 8.

Cousins, D.H., Sabatier, B., Begue, D., Schmitt, C., Hoppe-Tichy, T., 2005. Medication errors in intravenous drug preparation and administration: a multicentre audit in the UK, Germany and France. BMJ Quality & Safety, 14(3), 190–195.

Dwijayanti, S., Irawati, S., Setiawan, E., 2016. Profil Kompatibilitas Sediaan Obat Intravena dengan Pelarut pada Pasien Intensive Care Unit. Jurnal Farmasi Klinik Indonesia, 5(2), 84–97.

Fahimi, F., Ariapanah, P., Faizi, M., Shafaghi, B., Namdar, R., Ardakani, M.T., 2008. Errors in preparation and administration of intravenous medications in the intensive care unit of a teaching hospital: an observational study. Australian critical care, 21(2), 110–116.

Falconer, J.R., Steadman, K.J., 2017. Extemporaneously compounded medicines. Australian Prescriber, 40(1), 5–8.

FASHP, L.A.T., 2012. Handbook on Injectable Drugs, 17th Edition, 17 edition. ed. Amer Soc of Health System, Bethesda, Md.

Garot, D., Respaud, R., Lanotte, P., Simon, N., Mercier, E., Ehrmann, S., Perrotin, D., Dequin, P.-F., Guellec, C.L., 2011. Population pharmacokinetics of ceftriaxone in critically ill septic patients: a reappraisal. British Journal of Clinical Pharmacology, 72(5), 758–767.

Kanji, S., Lam, J., Johanson, C., Singh, A., Goddard, R., Fairbairn, J., Lloyd, T., Monsour, D., Kakal, J., 2010. Systematic review of physical and chemical compatibility of commonly used medications administered by continuous infusion in intensive care units. Critical care medicine, 38(9), 1890–1898.

Keers, R.N., Williams, S.D., Cooke, J., Ashcroft, D.M., 2015. Understanding the causes of intravenous medication administration errors in hospitals: a qualitative critical incident study. BMJ open, 5(3), e005948.

Langille, S.E., 2013. Particulate matter in injectable drug products. PDA journal of pharmaceutical science and technology, 67(3), 186–200.

Maharani, L., Achmad, A., Utami, E.D., 2013. Pengaruh Edukasi Apoteker Terhadap Sikap dan Pengetahuan Perawat tentang Pencampuran Sediaan Parenteral. Jurnal Keperawatan Soedirman, 8(2).

Merali, R., Orser, B.A., Leeksma, A., Lingard, S., Belo, S., Hyland, S., 2008. Medication safety in the operating room: teaming up to improve patient safety. Healthcare Quarterly (Toronto, Ont.), 11(3 Spec No.), 54–57.

Merry, A.F., Shipp, D.H., Lowinger, J.S., 2011. The contribution of labelling to safe medication administration in anaesthetic practice. Best Practice & Research Clinical Anaesthesiology, Safety in Anaesthesia 25(2), 145–159.

Ministry of Health of the Republic of Indonesia, 2016. Standard of Pharmaceutical Care in Hospital.

Ministry of Health of the Republic of Indonesia, 2009. Basic Guidelines for Sterile Dispensing.

Ministry of Health of the Republic of Indonesia., 2009. Guideline for i.v. Admixture and Handling Cytostatic.

Newton, D.W., 2009. Drug incompatibility chemistry. American Journal of Health-System Pharmacy, 66(4), 348–357.

Nguyen, H.-T., Nguyen, T.-D., van den Heuvel, E.R., Haaijer-Ruskamp, F.M., Taxis, K., 2015. Medication Errors in Vietnamese Hospitals: Prevalence, Potential Outcome and Associated Factors. PloS One, 10(9), e0138284.

Ong, W.M., Subasyini, S., 2013. Medication errors in intravenous drug preparation and administration. Med J Malaysia, 68(1), 52–57.

Pramanick, S., Singodia, D., Chandel, V., 2013. Excipient selection in parenteral formulation development. Pharma Times, 45(3), 65–77.

Putri, D.C.A., Yuliani, S.H., 2018. Evaluasi Peracikan Injeksi Seftriakson di Salah Satu Rumah Sakit Swasta di Semarang. Indonesian Journal of Clinical Pharmacy, 7(3), 143–153.

Salmasi, S., Khan, T.M., Hong, Y.H., Ming, L.C., Wong, T.W., 2015. Medication errors in the Southeast Asian countries: A systematic review. PLoS One, 10(9), e0136545.

Shargel, L., Yu, A., Wu, S., 2005. Biofarmasetika dan Farmakokinetika Terapan Edisi kedua. Airlangga University Press, Surabaya.

Srivastava, R.K., Kumar, S.S., 2017. An updated review: forced degradation study. World J Pharm Pharm Sci, 6(6), 709–26.

Strbova, P., Mackova, S., Miksova, Z., Urbanek, K., 2015. Medication errors in intravenous drug preparation and administration: a brief review. J Nurs Care, 4(285), 2167–1168.

Sudianto, M., Putri, D.C.A., Yuliani, S.H., 2018. Evaluation of Compounding Sterile Preparations for Hospitalized Pediatric Patients in “X” Hospital Semarang City, Indonesia. JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice), 8(3).

Trisnadewi, I.G.A., Widodo, A.D.W., 2014. Analysis of Antibiotic Usage in Patients With Bacteremia in The ICU Unit of Dr. Soetomo Hospital Surabaya 50(4), 8.

Vincent, J.-L., Rello, J., Marshall, J., Silva, E., Anzueto, A., Martin, C.D., Moreno, R., Lipman, J., Gomersall, C., Sakr, Y., Reinhart, K., Investigators, for the E.I.G. of, 2009. International Study of the Prevalence and Outcomes of Infection in Intensive Care Units. JAMA, 302(21), 2323–2329.

Webster, D., 2015. Sterile compounding: Pharmacy profession should take back control. Pharmacy Today, 21(3), 7.

Wong, G., Brinkman, A., Benefield, R.J., Carlier, M., De Waele, J.J., El Helali, N., Frey, O., Harbarth, S., Huttner, A., McWhinney, B., Misset, B., Pea, F., Preisenberger, J., Roberts, M.S., Robertson, T.A., Roehr, A., Sime, F.B., Taccone, F.S., Ungerer, J.P.J., Lipman, J., Roberts, J.A., 2014. An international, multicentre survey of β-lactam antibiotic therapeutic drug monitoring practice in intensive care units. Journal of Antimicrobial Chemotherapy, 69(5), 1416–1423.




DOI: http://dx.doi.org/10.24071/jpsc.1521045

Refbacks

  • There are currently no refbacks.


Copyright (c) 2018 Journal of Pharmaceutical Sciences and Community

 

 

 

 

 

 

 

                                

Web Analytics JPSC Stats