The Epigenetic Impact of Vegetables-Derived Dietary Compounds in Neurodegenerative Conditions : A Review

Vania Amanda Samor; Yurida Ni'ma Annisa; Muthi Ikawati; Nunung Yuniarti

doi:10.24071/jpsc.004490

The Epigenetic Impact of Vegetables-Derived Dietary Compounds in Neurodegenerative Conditions : A Review

Vania Amanda Samor⁽¹⁾, Yurida Ni'ma Annisa⁽²⁾, Muthi Ikawati⁽³⁾, Nunung Yuniarti^(4*),

(1) Master in Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Gadjah Mada, Jl. Sekip Utara, Sleman, Yogyakarta 55281
(2) Master in Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Gadjah Mada, Jl. Sekip Utara, Sleman, Yogyakarta 55281
(3) Macromolecular Engineering Laboratory, Department of Pharmacy Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281
(4) Pharmacology and Toxicology Laboratory, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281
(*) Corresponding Author

Abstract

Dietary compounds from the foods we eat on a daily basis offer several benefits; they help prevent disease and preserve health. The epigenetic advantages of the vegetables we eat every day are one of the benefits that have not been well-reported. Epigenetic pathways involving histone modification, DNA methylation, and alterations caused by miRNAs are extensively engaged in signal transmission, cell development, and death in various disease states, including brain cells. Through this narrative review collected from multiple studies available on reputable online databases until March 2022 shows the epigenetic advantages of various vegetables' content such as gallic acid, quercetin, kaempferol, apigenin, luteolin, resveratrol, genistein, sulforaphane, and diallyl disulfide in neurodegenerative conditions are summarized. However, in-depth investigations are still required to clarify these epigenetic mechanisms before these compounds are ready to be used in the future, as several studies still provide contradictory results

Keywords

Dietary compounds, epigenetic modification, neurodegenerative, vegetables

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References

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DOI: https://doi.org/10.24071/jpsc.004490