A Study of Potential Drug-Drug Interactions in Peptic Ulcer Patients in Dr. M. Djamil Hospital Padang in 2019

Lola Azyenela; Ringga Novelni; Viora Lusiana Satri

doi:10.24071/jpsc.003909

A Study of Potential Drug-Drug Interactions in Peptic Ulcer Patients in Dr. M. Djamil Hospital Padang in 2019

Lola Azyenela^(1*), Ringga Novelni⁽²⁾, Viora Lusiana Satri⁽³⁾,

(1) Faculty of Pharmacy, Perintis Indonesia University
(2) Padang State University
(3) Faculty of Pharmacy, Perintis Indonesia University
(*) Corresponding Author

Abstract

A peptic ulcer is a gastrointestinal tract disorder caused by excessive secretion of acid and pepsin by the gastric mucosa. The combined use of drugs in peptic ulcer management may potentially cause drug-to-drug interactions. Drug interactions are caused when two or more drugs interact and may affect the effectiveness of the other drugs. This study aims to analyze the potential drug reactions in peptic ulcer patients in the internal medicine ward of Dr. M. Djamil General Hospital Padang in 2019. This study was a descriptive, non-experimental study with retrospective data, while data analysis used Drugs.com and Medscape applications. The study results revealed that 29 patients fit the inclusion criteria and 5 (16.6%) potential drug pharmacokinetic interactions. The severity of drug interactions shows 4 cases (80%) with moderate severity potential and 1 case (20%) with minor severity potential. The study concluded that there were potential drug interactions in peptic ulcer patients in the internal medicine ward of Dr. M. Djamil General Hospital Padang in 2019.

Keywords

Data analysis; Drug interactions; Peptic ulcer

Full Text:

PDF

References

Astiti, P. M. A., Mukaddas, A., Illah, S.A., 2017. Identifikasi drug related problems (DRPs) pada pasien pediatri pneumonia komunitas di Instalasi Rawat Inap RSD Madani Provinsi Sulawesi Tengah. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 3(1), 57-63.

Bagus Prakoso, R., and Mutmainah, N., 2016. Potensi Interaksi Obat Pada Pasien Gangguan Lambung (Dispepsia, Gastritis, Tukak Peptik) Rawat Inap Di Rumah Sakit Keluarga Sehat Pati Tahun 2015 (Doctoral dissertation, Universitas Muhammadiyah Surakarta).

Datta-De, D., Roychoudhury, S., 2015. To be or not to be: The host genetic factor and beyond in Helicobacter pylori mediated gastro-duodenal diseases. World J. Gastroenterol., 21(10), 2883-2895.

Di Saverio, S., Bassi, M., Smerieri, N., Masetti, M., Ferrara, F., Fabbri, C., Ansaloni, L., Ghersi, S., Serenari, M., Coccolini, F., Naidoo, N., Sartelli, M., Tugnoli, G., Catena, F., Cennamo, V., Jovine, E., 2014. Diagnosis and treatment of perforated or bleeding peptic ulcers: 2013 WSES position paper. World J. Emerg. Surg., 9(45), 1-15.

Drugs.com, 2020., Prescription Drug Information, Interaction & Side Effects. Terdapat di [URL] https://www.drugs.com/drug_interactions.html (accessed 10.11.21).

Doligalski, C. T., Logan, A.T., Silverman, A., 2012. Drug interactions: a primer for the gastroenterologist. Gastroenterol. Hepatol., 8(6), 376-83.

Gokakin, A.K., Atabey, M., Koyuncu, A., Topcu, O., 2016. Peptic Ulcer Perforation in Elderly: 10 years' Experience of a Single Institution. International Journal of Gerontology, 10(4), 198-201.

Havard Health Publishing., 2014. Peptic Ulcer. Havard Medical School.

Kemenkes RI., 2013. Katalog Perpustakaan Badan PPSDMK Kemenkes. "Profil kesehatan indonesia tahun 2013."

Kuna, L., Jakab, J., Smolic, R., Raguz-Lucic, N., Vcev, A., Smolic, M., 2019. Peptic ulcer disease: a brief review of conventional therapy and herbal treatment options. J. Clin. Med., 8(2), 179.

Kuźnik, E., Dudkowiak, R., Adamiec, R., & Poniewierka, E., 2020. Diabetic autonomic neuropathy of the gastrointestinal tract. Przegląd Gastroenterologiczny, 15(2), 89-93.

Lee, T.Y., Tung, C.C., 2016. Management of Peptic Ulcer Bleeding Refractory to Endoscopic Treatment. Open Journal of Gastroenterology, 6, 159-165.

Lombeng, F., 2013. Hubungan Pola Makan Pasie Dengan Kejadian Gastritis di Wilayah Kerja Puskesmas Wawonasa. Manado: Universitas Pembangunan Indonesia.

Medscape, 2020, Drug Interaction Checker, [URL] http://reference.medscape.com/drug-interactionchecker) (accessed 10.11.21).

Nadia., 2018., Proton Inhibitor Use and Potential Drug Interaction in Outpatient. Jakarta: Univesitas Indonesia

Narayanan, M., Reddy, K.M., Marsicano, E., 2018. Peptic ulcer disease and Helicobacter pylori infection. Missouri Medicine, 115(3), 219.

Palleria, C., Di Paolo, A., Giofrè, C., Caglioti, C., Leuzzi, G., Siniscalchi, A., De Sarro, G., & Gallelli, L. 2013. Pharmacokinetic drug-drug interaction and their implication in clinical management. J. Res. Med. Sci., 18(7), 601.

Sari, M.N., 2012., Evaluasi Rasionalitas Penggunaan Kombinasi Obat Pada Pasien Tukak Peptik Di Ruang Rawat Inap RSUD Dr. Soebandi Jember; Universitas Negri Jember.

Saula, L.S., Hilmi, I.L., 2019. Potensi Interaksi Obat pada Resep Pasien Rawat Inap Pediatrik: Studi Retrospektif di Rumah Sakit Ibu dan Anak. HSG Journal, 4(2), 1-11.

Setiawati, S., Alwi, S., Sudoyo, A.W., Simadibrata, M. K., Setiyohadi, B., Syam, A.F., 2015. Buku Ajar Ilmu Penyakit Dalam Jilid II Edisi VI. Jakarta: Interna Publishing.

Serefko, A., Korona-Głowniak, I., Szopa, A., Drozd, M., Prystupa, A., Szymańska, J., Malm, A., Poleszak, E., 2021. Potential Drug-Drug Interactions Identified as Drug-Related Problems In The Treatment Of Hospitalized Patients With Gastritis And/Or Duodenitis Or Peptic Ulcer Disease In Lublin (Poland) Ñ An Observational Study. Acta Poloniae Pharmaceutica, 77(6), 909-919.

Søreide, K., Thorsen, K., Harrison, E. M., Bingener, J., Møller, M.H., Ohene-Yeboah, M., Søreide, J.A., 2015. Perforated peptic ulcer. Lancet, 386(10000), 1288-1298.

Stockley I., 2008. Drug Interaction A Source Book of Adserve Interaction, Their Mechanism, Clinical Importance and Management (8rd ed.)., University of Nottingham Medical School., England.

Sulochana, S.P., Syed, M., Chandrasekar, D.V., Mullangi, R., Srinivas, N.R., 2016. Clinical drug–drug pharmacokinetic interaction potential of sucralfate with other drugs: review and perspectives. Eur. J. Drug Metab Pharmacokinet, 41, 469-503.

Sumbar, D., 2015. Profil Kesehatan Sumatera Barat tahun 2014.

Strate, L.L., Singh, P., Boylan, M.R., Piawah, S., Cao, Y., Chan, A.T., 2016. A prospective study of alcohol consumption and smoking and the risk of major gastrointestinal bleeding in men. PloS one, 11(11), e0165278.

Zhang, B. B., Li, Y., Liu, X. Q., Wang, P. J., Yang, B., Bian, D.L., 2014. Association between vacA genotypes and the risk of duodenal ulcer: a meta-analysis. Mol. Biol. Rep., 41(11), 7241-7254.

DOI: https://doi.org/10.24071/jpsc.003909