LIPID AND SILVER NANOPARTICLES GELS FORMULATION  OF TEMPEH EXTRACT

Felicia Satya Christania; Rini Dwiastuti; Sri Hartati Yuliani

doi:10.24071/jpsc.002032

LIPID AND SILVER NANOPARTICLES GELS FORMULATION OF TEMPEH EXTRACT

Felicia Satya Christania^(1*), Rini Dwiastuti⁽²⁾, Sri Hartati Yuliani⁽³⁾,

(1) Sanata Dharma University
(2) Sanata Dharma University
(3) Sanata Dharma University
(*) Corresponding Author

Abstract

Tempeh extract is used in this study as an active ingredient in lipid nanoparticles and reductant in silver nanoparticles because tempeh is an authentic Indonesian food ingredient and is known to have the main content of isoflavones. Gel preparations were chosen to increase the acceptability and stability of lipid and silver nanoparticles. This research is aimed to formulate lipid nanoparticle gel formulations with tempeh extract as active substances and silver nanoparticle gel formulations with tempeh extract as bioreduction. Lipid nanoparticles were made from soy lecithin phospholipids by heating at 600C and sonication method for 30 minutes then the tempeh extract was added just before sonication. Silver nanoparticles were made by adding tempeh extract to the AgNO3 solution at 900C for 30 minutes. The average particle size of tempeh extract lipid nanoparticles was 130.03 nm and silver nanoparticle was 94.76 nm. The average viscosity of tempeh extract lipid nanoparticles gel was 4.02 d.Pa.s and silver nanoparticles was 4.22 d.Pa.s. The average spreadability of tempeh extract lipid nanoparticles gel was 4.37 cm and silver nanoparticles was 4.05 cm. The average pH value of tempeh extract lipid nanoparticles was 7.70 and silver nanoparticles was 7.33.

Keywords

gel; lipid nanoparticles; particle size; physical properties; silver nanoparticles; tempeh extract

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References

Ariyanta, H.A., 2014. Preparasi Nanopartikel Perak dengan Metode Reduksi dan Aplikasinya sebagai Antibakteri Penyebab Luka Infeksi. Indonesian Journal of Chemical Science, 10 (1), 3642.

Ayu, H., 2015. Kinetika Sintesis Nanopartikel Perak dari Larutan AgNO3 dengan Menggunakan Ekstrak Bungkil Biji Jarak Pagar sebagai Reduktor. Sekolah Pascasarjana Institut Pertanian Bogor.

Danciu, C., Soica, C., Csanyi, E., Ambrus, R., Feflea, S., and Peev, C., 2012. Changes in the anti-inflammatory activity of soy isoflavonoid genistein versus genistein incorporated in two types of cyclodextrin derivatives Changes in the anti-inflammatory activity of soy isoflavonoid genistein versus genistein incorporated in two typ. Chemistry Central Journal, 6 (1), 1.

Dwiastuti, R., Noegrohati, S., and Istyastono, E.P., 2016. Formulation and Physical Properties Observations of Soy Lecithin Liposome Containing 4- n -Butylresorcinol. American Institute of Physics, 160005 (1755), 15.

Dwiastuti, R., Noegrohati, S., Istyastono, E.P., and Marchaban, 2016. Metode Pemanasan dan Sonikasi Menghasilkan Nanoliposom dari Fosfolipid Lesitin Kedelai (Soy Lecithin). Jurnal Farmasi Sains dan Komunitas, 13 (1), 2327.

Dwinna, R., 2010. Lemak Padat Nanopartikel; Sintesis dan Aplikasi. Jurnal Kimia dan Kemasan, 32 (1), 2733.

Jafar, G., Darijanto, S.T., and Mauludin, R., 2015. Formulasi Solid Lipid Nanoparticle Ceramide. Jurnal Pharmascience, 2 (2), 8087.

Jain, D., Daima, H.K., Kachhwaha, S., and Kothari, S.L., 2009. Synthesis of Plant-Mediated Silver Nanoparticles Using Papaya Fruit Extract and Evaluation of Their Anti Microbial Activities. Digest Journal of Nanomaterials and Biostructures, 4 (3), 557563.

Jain D, Daima HK, Kachhwala S, and Kothari SL, 2009. Synthesis of plant-mediated silver nanoparticles using papaya fruit extract and evaluation of their anti microbial activities. Digest Journal of Nanomaterials and Biostructures , 4 (3), 557563.

Jain, J., Arora, S., Rajwade, J.M., Omray, P., Khandelwal, S., and Paknikar, K.M., 2009. Silver nanoparticles in therapeutics: Development of an antimicrobial gel formulation for topical use. Molecular Pharmaceutics, 6 (5), 13881401.

Latarissa, I.R., 2017. Review Artikel: Aplikasi Teknologi Nanopartikel pada Sediaan Kosmetik. Farmaka, 4 (November 2017), 115.

Maharini, I., Wigati, S., and Utami, D.T., 2017. Formulasi Nanopartikel Ekstrak Buah Naga (Hylocereus Polyrhizus) Sebagai Zat Warna Sediaan Lipstik. Chempublish Journal, 2 (1), 3843.

Maheswara, L., 2008. Optimasi Formula Gel Anti-Ageing Ekstrak Etil Asetat Isoflavon Tempe dengan Carbopol 940 sebagai Gelling Agent dan Propilenglikol sebagai Humectant : Aplikasi Desain Faktorial.

Martien, R., Adhyatmika, Irianto, I.D.K., Farida, V., and Sari, D.P., 2012. Perkembangan Teknologi Nanopartikel sebagai Sistem Penghantaran Obat. Farmaseutik Universitas Gadjah Mada, 8 (1), 133144.

zur Mhlen, A., Schwarz, C., and Mehnert, W., 1998. Solid lipid nanoparticles (SLN) for controlled drug delivery--drug release and release mechanism. European journal of pharmaceutics and biopharmaceutics?: official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 45 (2), 149155.

Muliadi, Arief, A., and Khadijah, 2015. Biosintensis Nanopartikel Logam Menggunakan Media Ekstrak Tanaman. Jurnal Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UIN Alauddin, 3 (2), 6472.

Park, E., Lee, S.M., Jung, I.K., Lim, Y., and Kim, J.H., 2011. Effects of genistein on early-stage cutaneous wound healing. Biochemical and Biophysical Research Communications, 410 (3), 514519.

Ramadon, D. and Munim, A., 2016. Pemanfaatan Nanoteknologi dalam Sistem Penghantaran Obat Baru untuk Produk Bahan Alam. Jurnal Ilmu Kefarmasian Indonesia, 14 (2) (2), 118127.

Sari Purwo Ismaya, M. Lutfi Firdaus, and Elvia Rina, 2017. Pembuatan Nanopartikel Perak dengan Bioreduktor Ekstrak Buah Muntingia calabura L untuk Analisis Logam Merkuri. Jurnal Pendidikan dan Ilmu Kimia, 1 (1), 2026.

Septyarin, I.P., 2017. Uji Aktivitas Antibakteri Nanopartikel Perak Terhadap Mutu Sediaan Farmasi Krim Jerawat. Journal of Chemistry Universitas Negeri Surabaya, 6 (1), 5963.

Sileikaite, A., Prosycevas, I., Puiso, J., Juraitis, A., and Guobiene, A., 2006. Analysis of Silver Nanoparticles Produced by Chemical Reduction of Silver Salt Solution. Material Science, 12 (4), 287291.

Tatang Wahyuni, Doni Sugiyama, Q.H., 2011. Sintesis Nanopartikel Perak Dan Uji Aktivitasnya. Arena Tekstil, 26 (1), 5560.

DOI: https://doi.org/10.24071/jpsc.002032