THE EFFECTIVENESS OF SOUTH SUMATRA COFFEE (Coffea arabica L.) EXTRACT CREAM IN BURN WOUND RECOVERY OF MALE WHITE MICE (Mus musculus)

Muhammad Romadhon; Dani Prasetyo

doi:10.24071/jpsc.003018

THE EFFECTIVENESS OF SOUTH SUMATRA COFFEE (Coffea arabica L.) EXTRACT CREAM IN BURN WOUND RECOVERY OF MALE WHITE MICE (Mus musculus)

Muhammad Romadhon^(1*), Dani Prasetyo⁽²⁾,

(1) Faculty of Midwifery and Nursing, University of Kader Bangsa, Jl. HM, Ryacudu No. 88 Palembang, 30452, Indonesia
(2) Faculty of Pharmacy, University of Kader Bangsa, Jl. HM, Ryacudu No. 88 Palembang, 30452, Indonesia
(*) Corresponding Author

Abstract

The effectiveness of South Sumatra coffee extract cream in burn wound recovery of white male mice had been analyzed. This research aims to ensure which one between immature and mature coffee bean that was better to recover burn wounds of male white mice after 14-day testing. The prepared concentrations for both coffee beans were 0.1%, 0.2%, and 0.3%. We then figured out that ethanol contained by young and old coffee beans had a recovery effect on burn wounds of male white mice (Mus musculus). Findings indicate that 0.3% of mature coffee beans were more effective in recovering burn wounds of male white mice (Mus musculus), in which the wound recovery percentage was close to that in the positive control (burnazin).

Keywords

burn wound; coffe extract; cream

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References

Akhoondinasab, M.R., Akhoondinasab, M., Saberi, M., 2014. Comparison of healing effect of aloe vera extract and silver sulfadiazine in burn injuries in experimental rat model. World journal of plastic surgery, 3(1), 29–34.

Aponno, J.V, Yamlean, P.V.Y., Supriati, H.S., 2014. Uji Efektivitas Sediaan Gel Ektrak Etanol Daun Jambu Biji (Psidium guajava Linn) Terhadap Penyembuhan Luka Yang Terinfeksi Bakteri Staphylococus aureus Pada Kelinci (Orytolagus cuniculus). Pharmacon, 3(3), 279–286.

Depkes RI, 2013. Riset kesehatan dasar, Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI, Indonesia.

Ekawati, K., Naniek, W., Mimiek, M., Syarifatun, K., 2012. Pengaruh konsentrasi ekstrak etanolik Daun Teh Hijau (Camellia Sinesis L.) dalam sediaan krim terhadap sifat fisik dan aktivitas antibakteri. Sains medika journal of health and medicine, 4(2), 147–156.

Elmitra, 2017. Buku Dasar-dasar Farmasetika dan Sediaan Semi Solid. Deepublish, Bengkulu.

Juwita, A.P., Yamlean, P.V.Y., Edy, H.J., 2013. Formulasi Krim Ektrak Etanol Daun Lamun (Syringodium isoetifolium) 2(02), 8–13.

Muljana, W., 2010. Bercocok Tanam Kopi. Aneka Ilmu, Semarang.

Murrukmihadi, M., Ananda, R., Handayani, T.U., 2012. Sediaan Krim Ekstra Etanolk Bunga Terhadap Sifat Fisik Dan Aktifitas Antibakteri Pada Staphylococcus aureus Effect of Carbomer 934 and Cetyl Alcohol Addittion as Emulsifier in Ethanolic Extract Hibiscus (Hibiscus rosa-sinenis L.) Cream on the Physical. Majalah Farmaseutik, 8(2), 152–157.

Nugroho, T., 2012. Luka Bakar & Artritis Reumatoid. Nuha Medika, Yogyakarta.

Paputungan, W.A., Lolo, W.A., Siampa, J.P., 2019. Aktivitas Antibakteri dan Analisis KLT- Bioautografi Dari Fraksi Biji Kopi Robusta (Coffea canephora Pierre ex A. Froehner). Pharmacon Jurnal Ilmiah Farmasi, 8(3), 100–108.

Puspitasari, A.D., Yuita, N.E., Sumantri, S., 2017. Krim Antioksidan Ektrak Etanol Daun Kopi Arabika (Coffea Arabica). Jurnal Ilmiah Teknosains, 3(2), 1–7.

Riansyah, Y., Mulqie, L., Choesrina, R., 2015. Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Ubi Jalar Ungu (Ipomoea batatas (L.) Lamk) terhadap Tikus Wistar Jantan, Prosiding Penelitian SpeSIA, Unisaba, 1(2), 630–636.

Sembiring, B.B., Ma’mun, Ginting, E.I., 2015. Pengaruh Kehalusan Bahan dan Lama Ektraksi Terhadap Mutu Ektrak Tumulawak (Curcuma xanthorriza Roxb). Buletin Penelitian Tanaman Rempah dan Obat, 17(2), 53–58.

Sjamsuhidajat, R., W.D.J., 2013. Buku Ajar Ilmu Bedah, Ed.3. CGC, Jakarta, Indonesia.

Solanum, L., Nsp, A.S., 2015. Antioxidant Activity Of Cream Dosage Form Of Tomato Extract (Solanum lycopersicum L.). Traditional Medicine Journal, 18(3), 132–140.

Sukmawati, E., 2018. Faktor - Faktor Yang Berhubungan Dengan Proses Penyembuhan Luka Post Sectio caesaria. Journal of Economics, Business & Accountancy Ventura, 21(10), 1–9.

Tiwari, V.K., 2012. Burn wound: How it differs from other wounds. Indian Journal of Plastic Surgery, 45(2), 364–373.

Wijaya, B.A., Citraningtyas, G. Wehantouw, F., 2014. Potensi Ekstrak Etanol Tangkai Daun Talas (Colocasia esculenta [L]) Sebagai Alternatif Obat Luka Pada Kulit Kelinci (Oryctolagus cuniculus). Pharmacon, 3(3), 2302-2493.

Wirastuty, R.Y., 2016. Uji Efektivitas Gel Ekstrak Etanol Kulit Batang Kayu Jawa (Lannea coromandelica) Pada Kelinci (Oryctolagus cuniculus) Sebagai Obat Penyembuhan Luka Bakar. Journal of Pharmaceutical Science and Herbal Technology, 1(1), 32–35.

Yuwono, H.S., 2014. The New Paradigm of Wound Management Using Coffee Powder. Global Journal of Surgery, 2(2), 25-29.

DOI: https://doi.org/10.24071/jpsc.003018