FORMULASI SEDIAAN ORALLY DISINTEGRATING TABLET ATENOLOL DENGAN SODIUM STARCH GLYCOLATE SEBAGAI SUPERDISINTEGRAN

Karina Citra Rani; Nani Parfati; Jessica Wangsa Putri

doi:10.24071/jpsc.00564

FORMULASI SEDIAAN ORALLY DISINTEGRATING TABLET ATENOLOL DENGAN SODIUM STARCH GLYCOLATE SEBAGAI SUPERDISINTEGRAN

Karina Citra Rani, Nani Parfati, Jessica Wangsa Putri

Abstract

Atenolol, a competitive beta (1)-selective adrenergic antagonists, has been widely used in hypertension therapy. Administration of conventional tablets of atenolol has limitation due to patient compliance in geriatric patients. Formulation of atenolol as orally disintegrating tablet (ODT) can improve the effectiveness of the drug and patient compliance in hypertension therapy. The objective of this study was to formulate orally disintegrating tablet of atenolol using sodium starch glycolate as superdisintegrant in two different concentrations (10% and 20%). Orally disintegrating tablets (ODT) of atenolol without superdisintegrant were used as a control in this study. It was found that orally disintegrating tablets (ODT) of atenolol which used 10% sodium starch glycolate have better wetting time (9.330.58 seconds), disintegration time (15.481.16 seconds), in vitro dispersion time (24.001.00 seconds), and dissolution efficiency (95.230.14 %) than orally disintegrating tablet (ODT) which used 20% sodium starch glycolate.

Keywords

orally disintegrating tablet (ODT); atenolol; hypertension; sodium starch glycolate

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References

Agoes G, 2012. Sediaan Farmasi Padat 1st edition. Penerbit ITB, Bandung.

Aulton, M., and Summers M., 2013. Tablet and Compaction. In: Pharmaceutics The Science of Dosage Form Design, 4th. Philadelphia: Churchill Livingstone, 397-439.

Chandrasekhar, P., Shahid Muhammad, S. and Niranjan Babu., M., 2013. Formulation and Evaluation of Oral Dispersible Tablets of Anti Hypertensive Drug Atenolol. International Journal of Pharmacy, 3 (2), 7984.

Dashora, K., 2013. Formulation and Evaluation of Fast Dissolving Tablets Atenolol. Journal of Chemical and Pharmaceutical Sciences, 6 (2), 113119.

Depkes RI, 2014. Farmakope Indonesia, Edisi V. Jakarta: Departemen Kesehatan Republik Indonesia, 178-180.

Dipiro, J.T., Talbert, R.L., Yee, G.C., Matzke, G.R., Wells, B.G., and Posey, L.M., 2008. Pharmacotherapy: A Pathophysiologic Approach Seventh Edition. New York: McGraw-Hill, 139-140.

Fu, Y., Yang, S., Jeong, S. H., Kimura, S. and Park, K., 2004. Orally Fast Disintegrating Tablets: Developments, Technologies, Taste-Masking and Clinical Studies. Critical Reviews in Therapeutic Drug Carrier Systems, 21(6), 433476.

Hahm, H. A. and Augsburger, L. L., 2008.Orally disintegrating tablets and related tablet formulations. In Pharmaceutical Dosage Forms: Tablets. New York, NY: Informa Healthhcare, 293312.

Hirani, J. J., Rathod, D. a. ands Vadalia, K. R., 2009. Orally Disintegrating Tablets: A Review. Tropical Journal of Pharmaceutical Research, 8 (2), 161172.

Kabir, A. K. L., Rahman, S. M., Jahan, M. A. and Rouf, A. S. S., 2010. Formulation Development and Evaluation of Mouth Dissolving Tablets of Loratadine. Stamford Journal of Pharmaceutical Sciences, 2 (2), 21012106. Khan, K.A., 1975. The Concept of Dissolution Eficiency. Journal of Pharmaceutical Science., 27 (1), 48-49.

Kumare, M. M., Marathe, R. P., Kawade, R. M., Ghante, M. H. and Shendarkar, G. R., 2013 Design of fast dissolving tablet of Atenolol using novel co-processed superdisintegrant. Asian Journal of Pharmaceutical and Clinical Research, 6(3), 8185.

Mangal, M., Thakral, S., Goswami M., and Ghai, P., 2012. Superdisintegrant: An update review. Akal College of Pharmacy and Technical Education Mastuana Sahib, (Pb), 26-35.

Pahwa, R. and Gupta, N., 2011. Superdisintegrants in the Development of Orally Disintegrating Tablets: A Review. International Journal of Pharmaceutical Sciences and Research, 2 (11), 27672780.

Shargel, L., Pong, S.W., and Yu, A.B., 2004. Applied Biopharmaceutics & Pharmacokinetics fifth edition. New York: McGraw-Hill, 457-458.

Sweetman, S.C., 2009. Martindale The Complete Drug Reference Thirty Six Edition.

DOI: https://doi.org/10.24071/jpsc.00564